<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3143 3143-30430 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48V, I54S, V82C, L90M   T4TS, L10V, R41K, I62V, L63A, I64V, A71V, I72V, V77I, I93L  
>3143-30430| codons 1-99
PQISLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIVGIGGFSKVRQYD
QVAVEICGHKVVGTVLIGPTPCNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y     K238KT K43E, V118I, K122E, D123DN, G196GE, Q197E, H208Y, R211K, D250E, A272P, K277R, Q334C, F346Y, R358RK, A360T, A376S, T377N, S379SC, T386I, K390KR  
>3143-30430| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIEEHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDTWT
VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGCGQWTYQIYQEPYKNLKTGKYARMKGT
HTNDVKQLTEAVQKISNECIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006