Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3143 | 3143-30430 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54S, V82C, L90M | T4TS, L10V, R41K, I62V, L63A, I64V, A71V, I72V, V77I, I93L |
| >3143-30430| codons 1-99 PQISLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIVGIGGFSKVRQYD QVAVEICGHKVVGTVLIGPTPCNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K238KT | K43E, V118I, K122E, D123DN, G196GE, Q197E, H208Y, R211K, D250E, A272P, K277R, Q334C, F346Y, R358RK, A360T, A376S, T377N, S379SC, T386I, K390KR |
| >3143-30430| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEEHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDTWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGCGQWTYQIYQEPYKNLKTGKYARMKGT HTNDVKQLTEAVQKISNECIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |