<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3142 3142-30414 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219D Y181C   V35L, E44D, K101Q, V118I, K122E, I135V, S162C, R211K, D218E, L228H, V245M, A272P, K277R, R284K, A288S, I293V, E297T, V317G, D324E, I326V, K350R, M357V, R358K, G359S, K390R  
>3142-30414| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
CQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPEDKHQKEPPFHWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLKGTKSLTEVVPLTTEAE
LELAENREILKEPVHGGYYDPSKELVAEIQKQGQGQWTYQIYQEPFKNLRTGKYARVKSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82S, I84V, L90M Q58E L10I, K14KR, I15V, L19I, K20R, M36I, I62V, L63P, H69Q, A71I, I93M  
>3142-30414| codons 1-99
PQITLWQRPIVTIRVGGQIREALLDTGADDTVLEEINLPGRWKPKMIVGIGGFVKVREYD
QVPIEICGQKIIGTVLVGPTPSNVIGRNLMTQMGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006