Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3142 | 3142-30414 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82S, I84V, L90M | Q58E | L10I, K14KR, I15V, L19I, K20R, M36I, I62V, L63P, H69Q, A71I, I93M |
| >3142-30414| codons 1-99 PQITLWQRPIVTIRVGGQIREALLDTGADDTVLEEINLPGRWKPKMIVGIGGFVKVREYD QVPIEICGQKIIGTVLVGPTPSNVIGRNLMTQMGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219D | Y181C | V35L, E44D, K101Q, V118I, K122E, I135V, S162C, R211K, D218E, L228H, V245M, A272P, K277R, R284K, A288S, I293V, E297T, V317G, D324E, I326V, K350R, M357V, R358K, G359S, K390R |
| >3142-30414| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPEDKHQKEPPFHWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLKGTKSLTEVVPLTTEAE LELAENREILKEPVHGGYYDPSKELVAEIQKQGQGQWTYQIYQEPFKNLRTGKYARVKSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |