Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3141 | 3141-30422 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75T, L210W, T215Y | K101E, Y181C, G190A | V108VI | V35VI, T39A, K43E, K102Q, V106VI, V118I, K122E, I142V, D177E, T200A, E203V, Q207E, H208Y, K223KE, L228H, V245Q, A272P, A288S, I293V, E297K, M357T, R358K, T386I, K390R | E40FY |
| >3141-30422| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAYLEEEGKISKIGPENPYNTPV FAIKKKNSDKWRKLTDFRELNKRTQDFWEVQLGIPHPAGLEQKKSITILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVASDLEIGQHRAKIVELREYLWRWGFYTPDKKHQEEPPFHWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, I84V, L90M | L89V | L10I, T12P, I13V, L19LP, K20M, E34Q, M36I, I62V, L63P, C67CY, A71T, P79AS, T91S, Q92R |
| >3141-30422| codons 1-99 PQITLWQRPIVPVKIGGQPMEALLDTGADDTVLQEINLPGRWKPKIIGGIGGFIKVRQYD QVPIEIYGHKTIGTVVVGSTPVNVIGRNVMSRIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |