Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3140 | 3140-30414 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M | Y181C | P4T, S68G, V118I, D123E, I135T, A158AS, D177E, T200A, R211S, F214L, P243S, I293V, E297A, V317A, I326V, Q334L, R358K, V381I, T386I, K390R, E399D |
| >3140-30414| codons 1-400 PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKRKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPSIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVGSDLEIGQHRAKIEELRQHLLSWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQSIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGAYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVKQLTEAVQKIATESIIIWGKIPKFRLPIQKETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54L, L90M | L33I, N88D | L10I, K20R, E35N, M36I, I62V, L63P, A71T, I85V, I93L |
| >3140-30414| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADNTVIENINLPGRWKPKMIGGIGGFLKVRQYD QVPIEICGHKTIGTVLVGPTPVNIVGRDLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |