<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3140 3140-30414 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N, I54L, L90M L33I, N88D L10I, K20R, E35N, M36I, I62V, L63P, A71T, I85V, I93L  
>3140-30414| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADNTVIENINLPGRWKPKMIGGIGGFLKVRQYD
QVPIEICGHKTIGTVLVGPTPVNIVGRDLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Q151M   Y181C   P4T, S68G, V118I, D123E, I135T, A158AS, D177E, T200A, R211S, F214L, P243S, I293V, E297A, V317A, I326V, Q334L, R358K, V381I, T386I, K390R, E399D  
>3140-30414| codons 1-400
PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKRKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPSIFQSSMTKILEPFRKQNPEIVI
CQYMDDLYVGSDLEIGQHRAKIEELRQHLLSWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQSIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTAEAE
LELAENREILKEPVHGAYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMKGA
HTNDVKQLTEAVQKIATESIIIWGKIPKFRLPIQKETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006