<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3139 3139-30414 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, I47V, I54M, I84V L10FI, L33F, M46V, Q58E I13V, K14R, I15V, E34Q, I62V, L63P, I72M, G73V, L89M, I93L  
>3139-30414| codons 1-99
PQITLWQRPIVTVRVGGQLKEALLDTGADDTIFQEMNLPGRWKPKVVGGIGGFMKVREYD
QVPIEICGHKAMVTVLVGPTPVNVIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70KR, L74V, M184V, T215F K219Q K103N   K20R, V35L, T39A, V118I, I135T, D177E, I178M, H208Y, R211K, F214L, K223Q, L228H, V245K, A272P, L283I, R284K, I329L, K350R, M357T, T369A, A376T, V381I, K390R  
>3139-30414| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEKEGKISKIGPENPYNTPV
FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
YQYVDDLYVGSDLEIGQHRTKIEELRQYLLKWGLFTPDQKHQQEPPFHWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIKGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLRTGKYARTRGA
HTNDVKQLAEAVQKITTESIIIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006