<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3136 3136-30404 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74V, L210W, T215Y K219E K101E, G190V   K20KR, T39A, E44ED, K49KR, V60I, T69N, V118I, K122E, D123N, V179T, V245T, D250E, A272P, L283I, R284K, E297R, K311R, P313T, I329L, M357V, K366R, T369A, A376V, T386A, K390KR, K395KR  
>3136-30404| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKISRIGPENPYNTPI
FAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDITI
YQYMDDLYVVSDLEIGQHRTKIEELRQHLWRWGFYTPDEKHQKEPPFLWMGYELHPDKWT
VQPITLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIKGTKALTEVIPLTREAE
LELAENREILRETVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARVRGA
HTNDVRQLAEAVQKIVTESIVIWGKAPKFRLPIQRETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, I84V, L90M L33F, G73S, L89V L10I, V11L, I13V, K14RT, G16GA, E34EQ, I62V, L63P, A71V, I72E, V77I, P79S  
>3136-30404| codons 1-99
PQITLWQRPILTVTIAGQLKEALLDTGADDTVFQEMNLPGRWKPKLIGGIGGFVKVRQYD
QVPIEICGHKVESTVLIGSTPANVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006