Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3136 | 3136-30404 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, L210W, T215Y | K219E | K101E, G190V | K20KR, T39A, E44ED, K49KR, V60I, T69N, V118I, K122E, D123N, V179T, V245T, D250E, A272P, L283I, R284K, E297R, K311R, P313T, I329L, M357V, K366R, T369A, A376V, T386A, K390KR, K395KR |
| >3136-30404| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKISRIGPENPYNTPI FAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDITI YQYMDDLYVVSDLEIGQHRTKIEELRQHLWRWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPITLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIKGTKALTEVIPLTREAE LELAENREILRETVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARVRGA HTNDVRQLAEAVQKIVTESIVIWGKAPKFRLPIQRETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | L33F, G73S, L89V | L10I, V11L, I13V, K14RT, G16GA, E34EQ, I62V, L63P, A71V, I72E, V77I, P79S |
| >3136-30404| codons 1-99 PQITLWQRPILTVTIAGQLKEALLDTGADDTVFQEMNLPGRWKPKLIGGIGGFVKVRQYD QVPIEICGHKVESTVLIGSTPANVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |