Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3135 | 3135-30523 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | K20KR, E35D, M36I, N37DE, I62V, L63P, A71T, V77VI |
| >3135-30523| codons 1-99 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEDIELPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | Y188L | V60I, V106VI, K122P, D123E, Q197K, T200A, E204ED, R211K, A272P, S322T, D324E, Q334E, K347KR, A371V, A376T, T386TA, K390R, E399D |
| >3135-30523| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DPEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGKHRAKIEDLRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPTKELIAEIQKQGEGQWTYQIYQEPFRNLKTGKYARMRGA HTNDVKQLTEVVQKITTESIVIWGKAPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |