Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3134 | 3134-30523 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, L90M | L33F, G73S | L10I, L19I, M36ML, I62V, L63P, C67F, H69N, A71I, I72L, V77I, V82I | K20KPQT |
| >3134-30523| codons 1-99 PQITLWQRPIVTIKIGGQITEALLDTGADDTIFEELNLPGRWKPKMVGGIGGFMKVRQYD QVPIEIFGNKILSTVLIGPTPINIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L210W, T215Y | K219R | Y188L | V35I, E40F, K43E, W88C, V106I, V118I, K122E, S162Y, I178M, G196E, T200D, E203K, Q207E, H208Y, R211K, W212M, K223E, E224K, L228R, A272P, K277R, T286A, I293V, E297R, G333E, Q334H, T386I | Y232H |
| >3134-30523| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTFLEEEGKISKIGPENPYNTPV FAIKKKDSDKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDMVI YQYMDDLLVGSDLEIEQHRDKIKELREYLWKMGFYTPDRKHQEKPPFRWMGHELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |