Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3133 | 3133-30428 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K103N, Y181C | V108I, V179VF | V35R, T39A, E44D, K101Q, V118I, K122E, I135T, S162C, I178IM, G196E, E203ED, R211RK, H221Y, L228H, A272P, K277R, I293V, E297K, D324E, Q334N, K350R, R356K, M357MV, R358K, E370C, Q373H, S379C, K395R |
| >3133-30428| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDMFI CQYVDDLYVGSDLEIEQHRTKIDELRQHLWKWGFYTPDNKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGNGQWTYQIYQEPFKNLRTGKYAKVKGA HTNDVKQLTCAVHKIATECIVIWGKTPKFKLPIQRETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82A, I84V | L10F, L24I, Q58E | T12N, I15V, L19P, K20M, L33L_L, E35ED, M36I, I62V, L63E, I64V, T74A, T91A |
| >3133-30428| codons 1-99 PQITLWQRPFVNIKVGGQPMEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVREYD QVEVEICGHKAIGAVLVGPTPANVIGRNLLAQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |