<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3133 3133-30428 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219N K103N, Y181C V108I, V179VF V35R, T39A, E44D, K101Q, V118I, K122E, I135T, S162C, I178IM, G196E, E203ED, R211RK, H221Y, L228H, A272P, K277R, I293V, E297K, D324E, Q334N, K350R, R356K, M357MV, R358K, E370C, Q373H, S379C, K395R  
>3133-30428| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDMFI
CQYVDDLYVGSDLEIEQHRTKIDELRQHLWKWGFYTPDNKYQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGNGQWTYQIYQEPFKNLRTGKYAKVKGA
HTNDVKQLTCAVHKIATECIVIWGKTPKFKLPIQRETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, V82A, I84V L10F, L24I, Q58E T12N, I15V, L19P, K20M, L33L_L, E35ED, M36I, I62V, L63E, I64V, T74A, T91A  
>3133-30428| codons 1-99
PQITLWQRPFVNIKVGGQPMEALIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVREYD
QVEVEICGHKAIGAVLVGPTPANVIGRNLLAQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006