Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3131 | 3131-30408 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50V, I54V, V82A | F53L | L10I, I15V, K20R, E35D, M36I, N37D, K55R, L63P, A71V |
| >3131-30408| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIDLPGRWKPKMIGGVGGLVRVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K101E, G190A | K43E, K49R, V90I, A98S, V118I, I135T, E138G, S162D, L228LF, L283I, R284K, I293V, E297A, G335D, R356K, M357R, G359S, K390R |
| >3131-30408| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISRIGPENPYNTPV FAIKKKNSTKWRKLMDFRELNKRTQDFWEIQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNGTPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFFWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIKGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |