<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3128 3128-31125 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 32

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, Y115F, M184V, L210W T215D Y181C, G190A K101H, V108I, Y318F V35I, T39A, V106I, V118I, K122E, I135T, Q174K, R211K, A272P, I293V, Q334P, A355S, M357V, G359S, A376S, K390R  
>3128-31125| codons 2-399
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKEGKISKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSITILDVGDAFFSIPLD
EDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVIC
QYVDDLYVASDLEIGQHRTKIEELRQHLWKWGFDTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAEL
ELAENREILKEPVHGVFYDPSKDLIAEIQKQGPGQWTYQIYQEPFKNLKTGKYSRVRSAH
TNDVKQLTEAVQKISTESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MIL, I47IV, I54V, V82L, L90M L23I, F53L L10V, I13V, K20R, E35D, M36V, N37E, R57K, D60DE, I62V, L63P, A71IV, V77I, I93L  
>3128-31125| codons 1-99
PQITLWQRPVVTVKIGGQLREAILDTGADDTVLEDVELPGRWKPKLVGGIGGLVKVKQYE
QVPIEICGHKVIGTVLIGPTPLNIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006