Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3128 | 3128-31125 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 32 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, Y115F, M184V, L210W | T215D | Y181C, G190A | K101H, V108I, Y318F | V35I, T39A, V106I, V118I, K122E, I135T, Q174K, R211K, A272P, I293V, Q334P, A355S, M357V, G359S, A376S, K390R |
| >3128-31125| codons 2-399 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKEGKISKIGPENPYNTPVF AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSITILDVGDAFFSIPLD EDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVIC QYVDDLYVASDLEIGQHRTKIEELRQHLWKWGFDTPDKKHQKEPPFLWMGYELHPDKWTV QPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAEL ELAENREILKEPVHGVFYDPSKDLIAEIQKQGPGQWTYQIYQEPFKNLKTGKYSRVRSAH TNDVKQLTEAVQKISTESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MIL, I47IV, I54V, V82L, L90M | L23I, F53L | L10V, I13V, K20R, E35D, M36V, N37E, R57K, D60DE, I62V, L63P, A71IV, V77I, I93L |
| >3128-31125| codons 1-99 PQITLWQRPVVTVKIGGQLREAILDTGADDTVLEDVELPGRWKPKLVGGIGGLVKVKQYE QVPIEICGHKVIGTVLIGPTPLNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |