Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3127 | 3127-30401 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L74V, M184V, L210W, T215Y | K101E | V35I, T39A, R83K, A98S, V118VI, K122E, I135V, E138A, Q174R, G196E, I202V, V245VE, A272P, A288S, E297KR, K311KR, D324E, I329L, Q334E, I341V, R356K, M357L, T362TS, K366KR, T369V, I375V, A376T, T377M, K390KR |
| >3127-30401| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI YQYVDDLYVGSDLEIEQHRTKVEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVIPLTREAE LELAENREILREPVHGVYYDPSKELIAELQKQGEGQWTYQVYQEPFKNLKTGKYAKLRGA HSNDVRQLVEAVQKVTMESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48GA, I54V, V82A, L90M | L33F, K43T, N83D | T4TS, L10I, T12P, L19EV, K20R, M36L, N37D, K55KR, R57K, I62V, L63P, A71V, T91TS, Q92K |
| >3127-30401| codons 1-99 PQISLWQRPIVPIKIGGQVREALLDTGADDTVFEELDLPGRWTPKLIAGIGGFVRVKQYD QVPIEICGHKVIGTVLVGPTPADIIGRNLMSKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |