<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3127 3127-30401 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48GA, I54V, V82A, L90M L33F, K43T, N83D T4TS, L10I, T12P, L19EV, K20R, M36L, N37D, K55KR, R57K, I62V, L63P, A71V, T91TS, Q92K  
>3127-30401| codons 1-99
PQISLWQRPIVPIKIGGQVREALLDTGADDTVFEELDLPGRWTPKLIAGIGGFVRVKQYD
QVPIEICGHKVIGTVLVGPTPADIIGRNLMSKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67DN, L74V, M184V, L210W, T215Y   K101E   V35I, T39A, R83K, A98S, V118VI, K122E, I135V, E138A, Q174R, G196E, I202V, V245VE, A272P, A288S, E297KR, K311KR, D324E, I329L, Q334E, I341V, R356K, M357L, T362TS, K366KR, T369V, I375V, A376T, T377M, K390KR  
>3127-30401| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSVNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI
YQYVDDLYVGSDLEIEQHRTKVEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVIPLTREAE
LELAENREILREPVHGVYYDPSKELIAELQKQGEGQWTYQVYQEPFKNLKTGKYAKLRGA
HSNDVRQLVEAVQKVTMESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006