Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3126 | 3126-30409 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L23I, K43T | L10I, T12P, I15V, D60E, I62V, L63P, L89LM, T91TS, Q92R |
| >3126-30409| codons 1-99 PQITLWQRPIVPIKVGGQLKEAILDTGADDTVLEEMNLPGRWTPKLIGGIGGFVKVRQYE QVPIEICGHKAIGTVLVGPTPANIIGRNMMSRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LV, T215Y | K219R | S3SR, P4S, V35VI, T39A, K43E, E44A, V106VI, V118I, K122E, I135T, T200A, E203K, Q207E, H208Y, L210Y, R211K, K223E, T286A, P294T, F346Y, R356K, G359S, V365I, T386I, K390R, E399D |
| >3126-30409| codons 1-399 PIRSIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIKELREYLYKWGFYTPDRKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVITLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPYKNLKTGKYAKMRSA HTNDIKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |