Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3124 | 3124-30407 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, L90M | L10V, E35D, M36I, N37D, L63P, I64V, C67S, V77I, I93L |
| >3124-30407| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTILEDIDLPGRWKPKIVGGIGGFIKVRQYD QIPVEISGHKAIGTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74V | K219H | Y181C | V108I | K11R, K20R, E28EK, K64N, K122E, I142IT, S162AD, L210V, R211K, D218E, A272P, K277R, T286A, A288P, E297K, G359S | E203T, P313V |
| >3124-30407| codons 1-399 PISPIETVPVRLKPGMDGPRVKQWPLTKEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAINKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKITELRQHLVKWGFTTPEHKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKPLTEVIPLTKEAE LELAENREILKEVVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |