Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3123 | 3123-30526 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A, L90M | L10F | K43I, L63P, A71V |
| >3123-30526| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTILEEMNLPGRWIPKIIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, Y115F, M184V, L210W, T215Y | Y181C | V108I | P4S, V118I, D123E, D177E, G196R, T200A, Q207E, H221Y, A272P, T286TA, E297K, A304E, I326V, I329IV, Q334H, G335GS, T338S, F346Y, N348NT, G359S, V365I, A371V, T377I |
| >3123-30526| codons 1-400 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAFFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYVDDLYVGSDLEIRQHRAKIEELREHLWRWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE LELEENREILKEPVHGVYYDPSKDLVAEVQKQGHSQWSYQIYQEPYKTLKTGKYARMRSA HTNDIKQLTEVVQKIAIESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |