Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3121 | 3121-30514 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, V82F, L90M | L33F, K43T, F53L, T74P | L10I, I13V, I15IV, K20R, E35D, M36I, N37E, D60E, I62IV, L63PT, I64V, C67Y |
| >3121-30514| codons 1-99 PQITLWQRPIVTVKVGGQLREALLDTGADDTVFEDIELPGRWTPKMIGGIGGLLKVRQYE QVTVEIYGHKAIGPVLVGPTPFNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | Y181C | V108I, F227L | V35M, T39A, K43KE, K122KE, Q174R, G196E, Q197K, T200A, E203K, Q207E, H208Y, R211K, K223E, L228Q, A272S, T286A, I293V, Q334D, R356K, M357V, E370Q, Q373H, K390R |
| >3121-30514| codons 1-398 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI CQYVDDLYVGSDLEIEKHRAKIKELREYLWKWGFYTPDKKHQEEPPLQWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDGQWTYQIYQEPFKNLKTGKYAKVRGA HTNDVKQLTQAVHKIATESIVIWGKTPKFRLPIQKETW |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |