<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3121 3121-30514 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54L, V82F, L90M L33F, K43T, F53L, T74P L10I, I13V, I15IV, K20R, E35D, M36I, N37E, D60E, I62IV, L63PT, I64V, C67Y  
>3121-30514| codons 1-99
PQITLWQRPIVTVKVGGQLREALLDTGADDTVFEDIELPGRWTPKMIGGIGGLLKVRQYE
QVTVEIYGHKAIGPVLVGPTPFNIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y   Y181C V108I, F227L V35M, T39A, K43KE, K122KE, Q174R, G196E, Q197K, T200A, E203K, Q207E, H208Y, R211K, K223E, L228Q, A272S, T286A, I293V, Q334D, R356K, M357V, E370Q, Q373H, K390R  
>3121-30514| codons 1-398
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI
CQYVDDLYVGSDLEIEKHRAKIKELREYLWKWGFYTPDKKHQEEPPLQWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDGQWTYQIYQEPFKNLKTGKYAKVRGA
HTNDVKQLTQAVHKIATESIVIWGKTPKFRLPIQKETW

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006