Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3120 | 3120-30331 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, Y115F, Q151M, M184V, L210W, T215Y | A62V, V75I, F77L, F116Y, K219E | K103N | V108I | E6EK, V35IM, T39A, T58N, R83RK, K122E, S162T, M164MI, T200A, E203N, H208FY, R211K, D218E, I257IL, A272P, I293V, E297K, I329L, G333E, Q334H, R356K, M357V, T369A, E370D, A376T, E399D |
| >3120-30331| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNNPV FVIKKKNSTKWRKLIDLRELNKKTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAFYSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQTSITKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKINELRQYLWKWGFYTPEEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDLQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQEHGQWTYQIYQEPFKNLKTGKYAKVRGA HTNDVKQLADAVQKITTESIVIWGKTPKFKLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82A, L90M | Q58QE | L10I, I15V, L19I, K20R, E35D, M36I, N37E, K55R, R57K, I62V, L63P, A71V, I72IV, I93L |
| >3120-30331| codons 1-99 PQITLWQRPIVTIKVGGQIREALLDTGADDTVLEDIELPGRWKPKLIGGIGGFVRVKEYD QVPIEICGHKVVGTVVVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |