<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3120 3120-30331 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, Y115F, Q151M, M184V, L210W, T215Y A62V, V75I, F77L, F116Y, K219E K103N V108I E6EK, V35IM, T39A, T58N, R83RK, K122E, S162T, M164MI, T200A, H208FY, R211K, D218E, I257IL, A272P, I293V, E297K, I329L, G333E, Q334H, R356K, M357V, T369A, E370D, A376T, E399D E203N
>3120-30331| codons 1-399
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNNPV
FVIKKKNSTKWRKLIDLRELNKKTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAFYSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQTSITKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRAKINELRQYLWKWGFYTPEEKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDLQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQEHGQWTYQIYQEPFKNLKTGKYAKVRGA
HTNDVKQLADAVQKITTESIVIWGKTPKFKLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, L76V, V82A, L90M Q58QE L10I, I15V, L19I, K20R, E35D, M36I, N37E, K55R, R57K, I62V, L63P, A71V, I72IV, I93L  
>3120-30331| codons 1-99
PQITLWQRPIVTIKVGGQIREALLDTGADDTVLEDIELPGRWKPKLIGGIGGFVRVKEYD
QVPIEICGHKVVGTVVVGPTPANIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006