<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3118 3118-30326 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, V75M, M184V, L210W, T215Y K219N, N348I L100I, K103N   E28EA, V35I, K43Q, E44D, V118I, D123E, S162SN, K166KQ, D177E, I178M, V179VI, G196E, R211K, A272P, I293V, E297K, Q334E, G359S, A371T, A376S, K390R K73Q
>3118-30326| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALIEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSTKWRQVMDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQNSMTQILEPFRKQNPEMII
YQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKILKTGKYARMRSA
HTNDVKQLTETVQKISTESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54A, I84V, L90M L10F, L33F I13V, L19I, K20KR, E34Q, E35D, M36MI, N37E, D60E, I62V, L63P, I64IM, I66F, A71V, I72L, Q92R  
>3118-30326| codons 1-99
PQITLWQRPFVTVKIGGQIREALLDTGADDTVFQDIELPGRWKPKMIGGIGGFAKVRQYE
QVPMEFCGHKVLGTVLVGPTPVNVIGRNLMTRIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006