Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3118 | 3118-30326 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54A, I84V, L90M | L10F, L33F | I13V, L19I, K20KR, E34Q, E35D, M36MI, N37E, D60E, I62V, L63P, I64IM, I66F, A71V, I72L, Q92R |
| >3118-30326| codons 1-99 PQITLWQRPFVTVKIGGQIREALLDTGADDTVFQDIELPGRWKPKMIGGIGGFAKVRQYE QVPMEFCGHKVLGTVLVGPTPVNVIGRNLMTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, V75M, M184V, L210W, T215Y | K219N, N348I | L100I, K103N | E28EA, V35I, K43Q, E44D, K73Q, V118I, D123E, S162SN, K166KQ, D177E, I178M, V179VI, G196E, R211K, A272P, I293V, E297K, Q334E, G359S, A371T, A376S, K390R |
| >3118-30326| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRQVMDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQNSMTQILEPFRKQNPEMII YQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKILKTGKYARMRSA HTNDVKQLTETVQKISTESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |