<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3117 3117-30325 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M G73T L10I, K20I, M36MI, L63P, A71I, I72V, I85V, I93L  
>3117-30325| codons 1-99
PQITLWQRPIVTIKIGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD
QIPIEICGHKIVTTVLVGPTPVNVVGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y K219R     E6EK, V35M, K43Q, E44D, K49KR, W88WC, V118I, K122E, R172RK, Q174H, G196E, Q207A, R211K, V245E, E248D, A272P, E297K, I329L, G333D, Q334H, M357T, A360T, V365I, K390R  
>3117-30325| codons 1-399
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEQDGKISRIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKHNPDIVI
YQYMDDLYVGSDLEIEQHRTKIEELRAHLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT
VQPIELPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQDHGQWTYQIYQEPFKNLKTGKYARTRGT
HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006