Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3117 | 3117-30325 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | G73T | L10I, K20I, M36MI, L63P, A71I, I72V, I85V, I93L |
| >3117-30325| codons 1-99 PQITLWQRPIVTIKIGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGHKIVTTVLVGPTPVNVVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219R | E6EK, V35M, K43Q, E44D, K49KR, W88WC, V118I, K122E, R172RK, Q174H, G196E, Q207A, R211K, V245E, E248D, A272P, E297K, I329L, G333D, Q334H, M357T, A360T, V365I, K390R |
| >3117-30325| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEQDGKISRIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKHNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRAHLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIELPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQDHGQWTYQIYQEPFKNLKTGKYARTRGT HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |