Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3116 | 3116-30321 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219N | Y181C, G190C | E6EDKN, K43E, V60I, K101Q, V118I, K122E, I135T, V179T, L228H, V245E, A272P, V276T, K277R, I293V, P294T, Q334S, R356K, G359S, V372I, A376C |
| >3116-30321| codons 1-399 PISPINTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDITI CQYVDDLYVCSDLEIGQHRTKIEELRQHLWRWGFYTPDNKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKTRQLCKLLRGTKALTEVVTLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGSGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAIQKICTESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L23I | L10I, E35ED, M36V, N37D, R41K, L63P, A71V, I93L |
| >3116-30321| codons 1-99 PQITLWQRPIVTIKIGGQLKEAILDTGADDTVLEDVDLPGKWKPKIIGGVGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |