<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3114 3114-30408 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, V75M, M184V, L210W, T215DY D67G, K219D L100I, K103N   K11T, T39A, E40F, K43E, S68G, V118I, K122E, D123N, I142T, T200A, Q207K, H208HY, R211A, D218E, L228R, R284K, A288S, E312EA, V317A, I329L, Q334QL, M357V, V365I, K390R, K395KR, E399D V35V*EL
>3114-30408| codons 1-399
PISPIETVPVTLKPGMDGPKVKQWPLTEEKIKALLEICAFLEEEGKISKIGPENPYNTPV
FAIKKKGGTKWRKVMDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRAKIEELRKYLWAWGFYTPEDKHQKEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKSLTEVIPLTEEAE
LELAENREILKAPVHGAYYDPSKDLIAELQKQGLGQWTYQIYQEPFKNLKTGKYARVRGA
HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQRETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I50IV, I54AV, V82AT, L90M L33LF L10I, K20R, E34EQ, E35D, M36I, N37E, D60E, L63P, A71V, L89LM, I93L  
>3114-30408| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVFQDIELPGRWKPKMIGGVGGFVKVRQYE
QIPIEICGHKVIGTVLVGPTPTNIIGRNMMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006