Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3114 | 3114-30408 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50IV, I54AV, V82AT, L90M | L33LF | L10I, K20R, E34EQ, E35D, M36I, N37E, D60E, L63P, A71V, L89LM, I93L |
| >3114-30408| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVFQDIELPGRWKPKMIGGVGGFVKVRQYE QIPIEICGHKVIGTVLVGPTPTNIIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, V75M, M184V, L210W, T215DY | D67G, K219D | L100I, K103N | K11T, T39A, E40F, K43E, S68G, V118I, K122E, D123N, I142T, T200A, Q207K, H208HY, R211A, D218E, L228R, R284K, A288S, E312EA, V317A, I329L, Q334QL, M357V, V365I, K390R, K395KR, E399D | V35V*EL |
| >3114-30408| codons 1-399 PISPIETVPVTLKPGMDGPKVKQWPLTEEKIKALLEICAFLEEEGKISKIGPENPYNTPV FAIKKKGGTKWRKVMDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRKYLWAWGFYTPEDKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKSLTEVIPLTEEAE LELAENREILKAPVHGAYYDPSKDLIAELQKQGLGQWTYQIYQEPFKNLKTGKYARVRGA HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |