Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3111 | 3111-30725 | France | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, L33F | L10V, I15V, L19V, K20M, E35N, M36IL, R41K, R57K, Q61N, I62V, L63P, C67Y, G73V, T74S |
| >3111-30725| codons 1-99 PQITLWQRPVVTIKVGGQVMEALIDTGADDTVFENLNLPGKWKPKLIGGIGGFVKVKQYD NVPIEIYGHKAIVSVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, T215Y | K219E, N348I | Y181C, G190A | V35T, T39D, E40F, K49KR, V60I, V106VI, V118I, D123E, I135C, I178IL, V179I, E194Q, G196GE, H208Y, L210Y, R211K, W212WLMR, L228H, A272P, K277R, T286TA, E297K, A376T, K385R, K390R, Q394L |
| >3111-30725| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICDFLEKEGKISRIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DKEFRKYTAFTIPSCNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLII CQYMDDLYVASDLQIEQHRTKIEELRQYLYKRGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARMRGA HTNDVKQLTEAVQKITTESIVIWGRTPKFRLPILKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |