<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3111 3111-30725 France 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L24I, L33F L10V, I15V, L19V, K20M, E35N, M36IL, R41K, R57K, Q61N, I62V, L63P, C67Y, G73V, T74S  
>3111-30725| codons 1-99
PQITLWQRPVVTIKVGGQVMEALIDTGADDTVFENLNLPGKWKPKLIGGIGGFVKVKQYD
NVPIEIYGHKAIVSVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, V75M, T215Y K219E, N348I Y181C, G190A   V35T, T39D, E40F, K49KR, V60I, V106VI, V118I, D123E, I135C, I178IL, V179I, E194Q, G196GE, H208Y, L210Y, R211K, L228H, A272P, K277R, T286TA, E297K, A376T, K385R, K390R, Q394L W212WLMR
>3111-30725| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICDFLEKEGKISRIGPENPYNTPI
FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL
DKEFRKYTAFTIPSCNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLII
CQYMDDLYVASDLQIEQHRTKIEELRQYLYKRGFYTPDEKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGRTPKFRLPILKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006