Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3107 | 3107-30507 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84V, L90M | F53L, G73A | L10Y, L19I, L33M, E34Q, R41K, D60E, L63P, A71V |
| >3107-30507| codons 1-99 PQITLWQRPYVTIKIGGQIKEALLDTGADDTIMQEMNLPGKWKPKIVGGIGGLMKVRQYE QIPIEICGHKVIATVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | K103N | K32R, T39A, K43Q, E44A, V118I, I142V, S162C, V179VI, T200S, H208Y, R211K, D218E, V245M, A272P, R284K, S322T, I329L, M357T, R358K |
| >3107-30507| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIRALVEICAELEQAGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRSKIEELRQYLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |