Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3106 | 3106-30425 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, V75M, M184V, L210W, T215Y | K219Q | L100I, K103N | E6D, K20R, E28EA, E44D, V60I, V111I, V118I, D123E, I135T, S162D, I178M, V179I, G196GE, T200A, E203D, H208Y, R211K, K223Q, L228HN, Q242H, A272P, L283I, T286A, I293V, T296TS, V317VA, G359S, A376V, S379C |
| >3106-30425| codons 1-400 PISPIDTVPVKLKPGMDGPRVKQWPLTAEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKVMDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDIGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDMII YQYVDDLYVGSDLEIEQHRAKIDELRQYLWKWGFYTPDQKHQQEPPFNWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGAKALTEVVPLSEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKIVTECIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82C, L90M | L10F, L33I, Q58E | K20R, L24F, E35D, M36I, N37DE, K55R, R57K, I62IV, L63P, A71V, I93L |
| >3106-30425| codons 1-99 PQITLWQRPFVTIKIGGQLREALFDTGADDTVIEDIELPGRWKPKLIGGIGGFVRVKEYD QVPIEICGHKVIGTVLVGPTPCNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |