<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3106 3106-30425 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82C, L90M L10F, L33I, Q58E K20R, L24F, E35D, M36I, N37DE, K55R, R57K, I62IV, L63P, A71V, I93L  
>3106-30425| codons 1-99
PQITLWQRPFVTIKIGGQLREALFDTGADDTVIEDIELPGRWKPKLIGGIGGFVRVKEYD
QVPIEICGHKVIGTVLVGPTPCNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, V75M, M184V, L210W, T215Y K219Q L100I, K103N   E6D, K20R, E28EA, E44D, V60I, V111I, V118I, D123E, I135T, S162D, I178M, V179I, G196GE, T200A, E203D, H208Y, R211K, K223Q, L228HN, Q242H, A272P, L283I, T286A, I293V, T296TS, V317VA, G359S, A376V, S379C  
>3106-30425| codons 1-400
PISPIDTVPVKLKPGMDGPRVKQWPLTAEKIKALVEICTELEKDGKISKIGPENPYNTPI
FAIKKKNSTKWRKVMDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDIGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDMII
YQYVDDLYVGSDLEIEQHRAKIDELRQYLWKWGFYTPDQKHQQEPPFNWMGYELHPDKWT
VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGAKALTEVVPLSEEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEAVQKIVTECIVIWGKTPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006