Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3105 | 3105-30418 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54M, V82A, I84V | V11VI, L33F | L10I, I13V, L63P, A71V, I93L |
| >3105-30418| codons 1-99 PQITLWQRPIITVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFMKVRQYD QIPIEICGHKVIGTVLVGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K103N, M230L | F227L | K43E, E44A, V60I, K64R, V111I, V118I, K122P, I135L, D177E, I178L, H208Y, K238S, V245E, K277R, Q278H, T286A, I293V, E297K, A355AT, M357MT, S379G, T386I, K390R |
| >3105-30418| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI FAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDIGDAYFSIPL DPDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWRWGFYTPDNKHQKEPPLLWLGYELHPDSWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRHLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYTRTRGA HTNDVKQLTEAVQKIATEGIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |