Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3103 | 3103-30317 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54T, V82A, L90M | L10I, T12P, L19I, K20R, M36I, I62V, L63P, A71V, I93L |
| >3103-30317| codons 1-99 PQITLWQRPIVPIKIGGQIREALLDTGADDTVLEEINLPGRWKPKLIVGIGGFTKVRQYD QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, L210W, T215Y | D67G, K219N | K238T | V60I, S68G, V118VI, D121Y, K122E, I135T, S162C, T200A, K223KE, V245T, A272P, T286TP, I293V, K311R, R358K, G359S, K390R |
| >3103-30317| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDNKHQEEPPFLWMGYELHPDTWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGPKALTEVVPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |