Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3102 | 3102-30320 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V | L33F, G73T | L10IV, K20R, E34EV, E35D, M36L, N37D, D60E, I62V, L63P, I72L, V77I, I93L |
| >3102-30320| codons 1-99 PQITLWQRPVVTIKIGGQLREALLDTGADDTVFVDLDLPGRWKPKIIGGIGGFMKVRQYE QVPIEICGHKALTTVLIGPTPVNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69S_VA, L74V, L210W, T215Y | A62V | K101E, Y181C, G190A | A98G | V35VI, R83K, Q174R, T200A, E203D, L228R, I293V, E297K, S322T, I329L, F346FY, R356K, K366R, A376T |
| >3102-30320| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSSKWRKVVDFRELNKKTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI CQYMDDLYVASDLEIGQHRAKIDELRQHLWRWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPTKDLIAELQKQGQGQWTYQIYQEPYKNLKTGKYAKMRGA HTNDVRQLTEAVQKITTESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |