Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3101 | 3101-30312 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46IL, I54V, L76V, V82A | L24I, L33F, F53FL | L10I, I13V, K20R, E35D, M36I, N37D, R41K, I62V, L63P, I64V |
| >3101-30312| codons 1-99 PQITLWQRPIVTVKIGGQLREALIDTGADDTVFEDIDLPGKWKPKLIGGIGGLVKVRQYD QVPVEICGHKAIGTVVVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184MV, L210W, T215Y | K219N | Y188L | V35I, S48T, V60I, V106VIL, V118I, K122E, I135T, K166R, Q174H, T200A, I202V, R211K, K277R, I293V, E297KPQT, D324DE, G333E, R356RK, A360T, T386I, K390R, E399D |
| >3101-30312| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKITKIGPENPYNTPI FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSLTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKHNPDIVI YQYVDDLLVGSDLEIGQHRAKVEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTTEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQEQGQWTYQIYQEPFKNLKTGKYAKMRGT HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |