Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3099 | 3099-30721 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219E | K101E, Y181I | V35L, T39A, D123E, I135IV, Q145M, S162Y, D177E, V179VI, E203D, H208Y, R211K, L228H, V245E, A272P, K277R, L283I, I293V, A355G, R356K, G359S, A360T, K390R |
| >3099-30721| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYMYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEIII IQYVDDLYVGSDLEIGQHRTKIDELRQYLWKWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYGKMRST HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V, L90M | L10F, Q58E | I13V, I15V, L19I, K20IT, E34Q, E35D, M36I, N37K, R57K, L63P, I64V, L89M |
| >3099-30721| codons 1-99 PQITLWQRPFVTVKVGGQITEALLDTGADDTVLQDIKLPGRWKPKIIGGIGGFVKVKEYD QIPVEICGHKAIGTVVVGPTPVNVIGRNMMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |