<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3099 3099-30721 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, I84V, L90M L10F, Q58E I13V, I15V, L19I, K20IT, E34Q, E35D, M36I, N37K, R57K, L63P, I64V, L89M  
>3099-30721| codons 1-99
PQITLWQRPFVTVKVGGQITEALLDTGADDTVLQDIKLPGRWKPKIIGGIGGFVKVKEYD
QIPVEICGHKAIGTVVVGPTPVNVIGRNMMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219E K101E, Y181I   V35L, T39A, D123E, I135IV, Q145M, S162Y, D177E, V179VI, E203D, H208Y, R211K, L228H, V245E, A272P, K277R, L283I, I293V, A355G, R356K, G359S, A360T, K390R  
>3099-30721| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSVNNETPGIRYMYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEIII
IQYVDDLYVGSDLEIGQHRTKIDELRQYLWKWGFYTPDEKHQKEPPFHWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYGKMRST
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006