Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3097 | 3097-30325 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, L76V, I84V, L90M | L10F | I13V, K20I, E34K, M36I, K55R, I62V, L63P, H69K, A71V, P79D, I93M |
| >3097-30325| codons 1-99 PQITLWQRPFVTVKIGGQLIEALLDTGADDTVLKEINLPGRWKPKLIGGIGGFLRVRQYD QVPIEICGKKVIGTVVVGDTPVNVIGRNLMTQMGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, T215F | K219Q | Y181C, G190S | A98G | V35IM, K122E, D123E, I167V, D177E, V179I, I202V, H208Y, R211K, L228H, Q242H, A272P, K277R, L283I, E297K, M357MI, R358RK, G359S |
| >3097-30325| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKVLEPFRKQNPEIII CQYMDDLYVSSDLEIGQHRTKVEELRQYLLKWGFFTPDQKHQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARIKSA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |