Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3096 | 3096-30415 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47A, L90M | L10F, Q58E | I15V, E35D, M36I, I62V, L63P, A71T |
| >3096-30415| codons 1-99 PQITLWQRPFVTIKVGGQLKEALLDTGADDTILEDINLPGRWKPKIAGGIGGFIKVREYD QVPIEICGHKTIGTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74I, M184V, T215F | K219Q | A98G | P4PT, K20R, V35I, K43KE, T69N, V106VI, V118I, K122E, S162D, D177DN, I178IM, T200A, E203D, H208Y, R211K, F214L, L228LH, V245E, K249KQ, R284K, T286A, A288AS, I293V, D324E, M357T, D364E, V365I, A376T, K390R, E399D | K64KHNQ |
| >3096-30415| codons 1-399 PISTIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEEEGKISKIGPENPYNTPV FAIQKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPNMVI YQYVDDLYVGSDLEIGQHRAKIDELRQYLLKWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIELPEQDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKSLTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNEIKQLTEAVQKITTESIVIWGKTPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |