<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3095 3095-30414 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70G, L74V, Y115F, M184V, T215F N348I L100I, K103N   V35T, T39L, V60I, A98S, K122E, I135T, I142V, I202IV, F214L, A272P, K277KR, A288S, I293V, I329L, I341IV, M357T, K385R  
>3095-30414| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICLEMEKEGKISKIGPENPYNTPI
FAIKKKNSTGWRKVVDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAFFSVPL
DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGLFTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQVYQEPFKILKTGKYARTRGA
HTNDVKQLTEAVQKIATESIVIWGRTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A, L90M L33F, K43T, G73S L10I, I13V, G16A, I62V, L63P, A71V, I72R  
>3095-30414| codons 1-99
PQITLWQRPIVTVKIAGQLKEALLDTGADDTVFEEMNLPGRWTPKIIGGIGGFVKVRQYD
QVPIEICGHKVRSTVVVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006