Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3094 | 3094-30331 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L33F, G73S | L10I, L24M, E35D, M36I, I62V, L63P, C67F, H69Q, K70E, A71IV |
| >3094-30331| codons 1-99 PQITLWQRPIVTIKIGGQLKEALMDTGADDTVFEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEIFGQEVISTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, Y115F, M184V | L100I, K103N | P225H | V35L, K102Q, K122E, T200A, H221Y, V245E, T286A, K311KR, D324E, I329L, Y354YH, S379C, K390R |
| >3094-30331| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKQNKSVTVLDVGDAFFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKYQKEHPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILREPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKHARMRGA HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |