<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3093 3093-30401 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54M, L90M L10F, L33F, Q58E, G73S, L89V K20V, E35N, M36I, R41K, K55R, D60E, Q61E, I62V, L63P, A71V, I72T, I85V, I93L  
>3093-30401| codons 1-99
PQITLWQRPFVTIKIGGQLVEALLDTGADDTVFENINLPGKWKPKIIGGIGGFMRVREYE
EVPIEICGHKVTSTVLVGPTPVNIVGRNVMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, T215F K219Q     E6EG, K20R, K32KQ, T39A, V60I, T69N, V118I, K122E, I135T, E138A, K166R, Q174QR, V179I, I202V, R211K, F214L, A272P, K277R, I293V, P313PL, D324E, R356RK, A360T, T369TA, I375V, A376V, S379C, T386A  
>3093-30401| codons 1-399
PISPIGTVPVKLKPGMDGPRVKQWPLTEEKIQALVEICAELEKEGKISKIGPENPYNTPI
FAIKKKNSNKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKRNPDIII
YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGLFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKELVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGT
HTNDVKQLAEAVQKVVTECIVIWGKAPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006