Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3093 | 3093-30401 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L90M | L10F, L33F, Q58E, G73S, L89V | K20V, E35N, M36I, R41K, K55R, D60E, Q61E, I62V, L63P, A71V, I72T, I85V, I93L |
| >3093-30401| codons 1-99 PQITLWQRPFVTIKIGGQLVEALLDTGADDTVFENINLPGKWKPKIIGGIGGFMRVREYE EVPIEICGHKVTSTVLVGPTPVNIVGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, T215F | K219Q | E6EG, K20R, K32KQ, T39A, V60I, T69N, V118I, K122E, I135T, E138A, K166R, Q174QR, V179I, I202V, R211K, F214L, A272P, K277R, I293V, P313PL, D324E, R356RK, A360T, T369TA, I375V, A376V, S379C, T386A |
| >3093-30401| codons 1-399 PISPIGTVPVKLKPGMDGPRVKQWPLTEEKIQALVEICAELEKEGKISKIGPENPYNTPI FAIKKKNSNKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKRNPDIII YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKELVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGT HTNDVKQLAEAVQKVVTECIVIWGKAPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |