Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3090 | 3090-30925 | France | 2003 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82C, I84V | V11I, L33I, K43T, F53FL | L10I, T12M, I13V, K14R, L19P, K20I, A22V, M36I, R41K, K55R, H69K, K70R, I72V, T74S, L89I, T91S |
| >3090-30925| codons 1-99 PQITLWQRPIIMVRIGGQPIEVLLDTGADDTVIEEINLPGKWTPKIVGGIGGLVRVRQYD QILIEICGKRAVGSVLVGPTPCNVIGRNILSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, M184V, L210W, T215F | K219Q | K103N, Y181C | A98G, V108I | V35T, T39A, K49R, V60I, V90I, K122E, I135V, E169K, K173T, Q174K, D177E, I178M, T200A, E203D, Q207E, D218E, L228H, V245Q, E248D, D250E, L283I, A288T, E291D, V292I, I293V, P294T, S322T, G335D, M357Q, G359S, A371V, I375V, A376S, K390R, K395R | S162E |
| >3090-30925| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISRIGPENPYNTPI FAIKKKNSDRWRKIVDFRELNKRTQDFWEIQLGIPHPGGLKKNKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQESMTKILKPFRTKNPEMVI CQYVDDLYVGSDLEIGQHRAKIDELREHLWRWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKTLTDIVTLTEEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARQRSA HTNDVKQLTEVVQKVSTESIVIWGKTPKFRLPIQRETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |