Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3087 | 3087-30331 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R, N348I | K103N | K43N, E44D, K101S, V118I, D123E, I135V, Q174E, Q207A, R211K, A272P, K277R, I293V, I329L, G333E, I341F, T386I |
| >3087-30331| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLSKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRAHLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQEQGQWTYQFYQEPFKILKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L33F | L10R, K20R, E35D, M36I, N37D, L63P, A71V, V77VI, T91A, I93L |
| >3087-30331| codons 1-99 PQITLWQRPRVTIKIGGQLREALLDTGADDTVFEDIDLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHKVIGTVLIGPTPANIIGRNLLAQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |