Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3086 | 3086-30331 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I | L10I, T12E, N37D, D60E, L63P, A71T, V77I |
| >3086-30331| codons 1-99 PQITLWQRPIVEIKIGGQLKEALIDTGADDTVLEEMDLPGRWKPKIIGGIGGFVKVRQYE QIPIEICGHKTIGTVLIGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K20R, V35I, K43KQ, E44ED, I135T, S162CY, Q207E, R211K, V245K, A272P, R284K, E297R, I329L, T338S, M357I, R358K, G359S, K390R, K395R, E399D |
| >3086-30331| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGTKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWSYQIYQEPFKNLKTGKYARIKSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQRETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |