<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3085 3085-30515 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Y115F, Q151M A62V, K70T, V75I, F77L, F116Y Y188L   P4S, V35M, S68R, K101Q, V106I, K122E, S162C, I167V, R172K, I202V, H221Y, A272P, K277R, E297K, D324E, I326V, Q334L, R358K, T369A, T377K, T386I, K390R  
>3085-30515| codons 1-400
PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV
FVIKRKDRTTWRKLIDLRELNKRTQDFWEVQLGIPHPAGLQKKKSITVLDVGDAFYSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQCSMTKVLEPFKKQNPDIVI
YQYMDDLLVGSDLEIGQHRTKVEELRQHLLRWGFTTPDKKYQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKELVAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMKGA
HTNDVKQLAEAVQKIAKESIVIWGKIPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54V, V82A, L90M L33F, G73S L10V, I13V, K20R, E35D, M36I, N37D, K43I, K55KR, I62V, L63P, A71V, I72T  
>3085-30515| codons 1-99
PQITLWQRPVVTVKIGGQLREALLDTGADDTVFEDIDLPGRWIPKIIGGVGGFVRVRQYD
QVPIEICGHKVTSTVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006