Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3085 | 3085-30515 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115F, Q151M | A62V, K70T, V75I, F77L, F116Y | Y188L | P4S, V35M, S68R, K101Q, V106I, K122E, S162C, I167V, R172K, I202V, H221Y, A272P, K277R, E297K, D324E, I326V, Q334L, R358K, T369A, T377K, T386I, K390R |
| >3085-30515| codons 1-400 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FVIKRKDRTTWRKLIDLRELNKRTQDFWEVQLGIPHPAGLQKKKSITVLDVGDAFYSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQCSMTKVLEPFKKQNPDIVI YQYMDDLLVGSDLEIGQHRTKVEELRQHLLRWGFTTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKELVAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVKQLAEAVQKIAKESIVIWGKIPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L33F, G73S | L10V, I13V, K20R, E35D, M36I, N37D, K43I, K55KR, I62V, L63P, A71V, I72T |
| >3085-30515| codons 1-99 PQITLWQRPVVTVKIGGQLREALLDTGADDTVFEDIDLPGRWIPKIIGGVGGFVRVRQYD QVPIEICGHKVTSTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |