Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3084 | 3084-30520 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54S, V82A | L33F, F53L | L10IV, I13V, G16E, N37D, I62V, L63T, A71I, V77I, I93L |
| >3084-30520| codons 1-99 PQITLWQRPVVTVKIEGQLKEALLDTGADDTVFEEMDLPGRWKPKLIVGIGGLSKVRQYD QVTIEICGHKIIGTVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70E, M184V, L210W, T215Y | K20R, E36K, K43E, K49R, D123E, E169D, D177E, L228N, A272P, L283I, E297EA, Q334R, G335D, G359S, A371V, I375V, T377Q |
| >3084-30520| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVKICTELEEEGKISRIGPENPYNTPV FAIKKKNSTEWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFNWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGRDQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKVAQESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |