Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3083 | 3083-30313 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74IV, M184V, L210W, T215Y | Y181YC | V108I | K20R, V35VI, K43E, E44D, K102Q, V118I, K122E, D123E, S162Y, V179VI, V189VI, E203K, Q207E, H208HY, R211K, A272P, K277R, T286A, I293V, E297R, G335S, N348T, R356K, G359S, A360T, K366R, A371V, K385KR, K390R | K223PT |
| >3083-30313| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTILDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII CQYVDDLYIGSDLEIGQHRTKIKELREYLWKWGFYTPDKKHQTEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQSQWTYQIYQEPFKTLKTGKYAKMRST HTNDVRQLTEVVQKIATESIVIWGRTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82A, L90M | K43T, F53L, G73S, L89V | L10V, T12I, I13V, G16A, K20I, M36I, K55R, L63P, A71V |
| >3083-30313| codons 1-99 PQITLWQRPVVIVKIAGQLIEALLDTGADDTILEEINLPGRWTPKIVGGIGGLVRVRQYD QIPIEICGHKVISTVLVGPTPANIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |