<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3082 3082-30311 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y V75M, N348I K101EQ, Y181C, G190A A98G, V108I V35I, T39TA, E40F, K43E, W88C, I94L, V118I, K122E, D123DE, Q174R, V189I, T200A, Q207K, H208F, R211D, H221Y, L228HN, A272PS, K275R, K277R, T286TA, A288S, I293V, Q334L, I341F, T386I, K390R  
>3082-30311| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAFLEEEGKISKIGPENPYNTPV
FAIKKKNSDKWRKLMDFRELNKRTQDFCEVQLGLPHPGGLQKKKSVTILDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI
CQYVDDLYIASDLEIGQHRAKIEELRKFLWDWGFYTPDKKYQKEPPFNWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIRVRQLCKLLRGAKSLTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQFYQEPFKILKTGKYARMRGA
HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82S L10F, L24I, L33F, Q58E, G73C T12TP, I13V, K14KR, I15V, K20R, E35D, M36L, N37D, K55R, Q61E, I62V, L63P, I72T, V77I  
>3082-30311| codons 1-99
PQITLWQRPFVPVRVGGQLREALIDTGADDTVFEDLDLPGRWKPKLIGGIGGFVRVREYD
EVPIEICGHKATCTVLIGPTPSNIIGRNLLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006