Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3082 | 3082-30311 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82S | L10F, L24I, L33F, Q58E, G73C | T12TP, I13V, K14KR, I15V, K20R, E35D, M36L, N37D, K55R, Q61E, I62V, L63P, I72T, V77I |
| >3082-30311| codons 1-99 PQITLWQRPFVPVRVGGQLREALIDTGADDTVFEDLDLPGRWKPKLIGGIGGFVRVREYD EVPIEICGHKATCTVLIGPTPSNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | N348I | K101EQ, Y181C, G190A | A98G, V108I | V35I, T39TA, E40F, K43E, W88C, I94L, V118I, K122E, D123DE, Q174R, V189I, T200A, Q207K, H208F, R211D, H221Y, L228HN, A272PS, K275R, K277R, T286TA, A288S, I293V, Q334L, I341F, T386I, K390R |
| >3082-30311| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAFLEEEGKISKIGPENPYNTPV FAIKKKNSDKWRKLMDFRELNKRTQDFCEVQLGLPHPGGLQKKKSVTILDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI CQYVDDLYIASDLEIGQHRAKIEELRKFLWDWGFYTPDKKYQKEPPFNWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIRVRQLCKLLRGAKSLTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQFYQEPFKILKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |