Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3081 | 3081-30311 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54S, V82A, L90M | L33F, Q58E | L10IV, I13V, E34Q, R41RK, I62V, L63PS, K70T, A71V, V77VI, I93L |
| >3081-30311| codons 1-99 PQITLWQRPVVTVKIGGQLKEALLDTGADDTVFQEMNLPGKWKPKLIVGIGGFSKVREYD QVSIEICGHTVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69S_SG, M184MV, T215Y | V75VA | V108VI | K64R, V118VI, D123E, I135T, I142V, S162C, G196E, R211A, L228LH, A288S, D324E, Q334R, M357T, R358K, T386I, E399D |
| >3081-30311| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIRKKDSSKWRKLADFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLAWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGRGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |